Get Targeted Learning: Causal Inference for Observational and PDF

By Mark J. van der Laan

ISBN-10: 1441997814

ISBN-13: 9781441997814

The information occupation is at a special element in historical past. the necessity for legitimate statistical instruments is larger than ever; info units are mammoth, frequently measuring millions of measurements for a unmarried topic. the sector is able to stream in the direction of transparent target benchmarks lower than which instruments could be evaluated. special studying permits (1) the total generalization and usage of cross-validation as an estimator choice software in order that the subjective offerings made by means of people at the moment are made by means of the laptop, and (2) concentrating on the precise of the chance distribution of the information towards the objective parameter representing the clinical query of curiosity.

This ebook is aimed toward either statisticians and utilized researchers attracted to causal inference and common impact estimation for observational and experimental info. half I is an available advent to large studying and the specific greatest chance estimator, together with similar techniques essential to comprehend and observe those equipment. elements II-IX deal with complicated information buildings and themes utilized researchers will instantly realize from their very own examine, together with time-to-event results, direct and oblique results, positivity violations, case-control reviews, censored facts, longitudinal facts, and genomic studies.

"Targeted studying, through Mark J. van der Laan and Sherri Rose, fills a miles wanted hole in statistical and causal inference. It protects us from losing computational, analytical, and knowledge assets on beside the point points of an issue and teaches us the best way to concentrate on what's appropriate – answering questions that researchers actually care about."
-Judea Pearl, desktop technological know-how division, college of California, Los Angeles

"In precis, this e-book might be at the shelf of each investigator who conducts observational study and randomized managed trials. The recommendations and technique are foundational for causal inference and whilst remain actual to what the information handy can say concerning the questions that encourage their collection."
-Ira B. Tager, department of Epidemiology, collage of California, Berkeley

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Get Targeted Learning: Causal Inference for Observational and PDF

The facts career is at a special aspect in heritage. the necessity for legitimate statistical instruments is bigger than ever; facts units are enormous, frequently measuring thousands of measurements for a unmarried topic. the sector is able to flow in the direction of transparent aim benchmarks lower than which instruments should be evaluated.

Extra info for Targeted Learning: Causal Inference for Observational and Experimental Data

Example text

2 Data . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Statistical Model . . . . . . . . . . . . . . . . . . . . . 4 Parameter of Interest . . . . . . . . . . . . . . . . . . . . 5 Effect Modification: Simplified Case . . . . . . . . . . . . . 1 Obtaining Q0n , an Initial Estimate of Q0 . . . . . . . . 2 Calculating the Optimal Fluctuation . . . . . . . . . 3 Obtaining Q∗n , a Targeted Estimate of Q0 .

Xv List of Contributors . . . . . . . . . . . . . . . . . . . . . . . . xliii Abbreviations and Notation . . . . . . . . . . . . . . . . . . . . . xlvii Models, Inference, and Truth . . . . . . . . . . . . . . . . . . . . M. Starmans li Part I Targeted Learning: The Basics 1 The Open Problem . . . . . . . . . . . . . . . . . . . . . . . Sherri Rose, Mark J. 1 Learning from Data .

143 9 Marginal Structural Models . . . . . . . . . . . . . . . . . . . 1 Impact of Missing Doses on Virologic Failure . . . . . . . . . 2 Data . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Statistical Model . . . . . . . . . . . . . . . . . . . . . 4 Parameter of Interest . . . . . . . . . . . . . . . . . . . . 5 Effect Modification: Simplified Case . . . . . . . . . . . . . 1 Obtaining Q0n , an Initial Estimate of Q0 .

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Targeted Learning: Causal Inference for Observational and Experimental Data by Mark J. van der Laan


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