Get Metchnikoff and the Origins of Immunology: From Metaphor to PDF

By Alfred I. Tauber

ISBN-10: 019506447X

ISBN-13: 9780195064476

ISBN-10: 142373470X

ISBN-13: 9781423734703

This interesting highbrow heritage is the 1st severe research of the paintings of Elie Metchnikoff, the founder of glossy immunology. Metchnikoff authored and championed the idea that phagocytic cells actively guard the host physique opposed to pathogens and diseased cells. His software constructed from comparative embryological experiences that sought to set up genealogical relatives among species on the sunrise of the Darwinian revolution. during this clinical biography, Tauber and Chernyak discover ore Metchnikoff's improvement as an embryologist, displaying the way it ready him to suggest his idea of host-pathogen interplay. They speak about the profound influence of Darwin's concept of evolution on Metchnikoff's growth, and the impact of nineteenth century debates on vitalism, teleology, and mechanism. As a case research of clinical discovery, this paintings deals lucid perception into the method of artistic technology and its dependence on cultural and philosophic resources. Immunologists and historians of technological know-how and medication will locate it an soaking up and obtainable account of a striking person.

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Additional info for Metchnikoff and the Origins of Immunology: From Metaphor to Theory (Monographs on the History and Philosophy of Biology)

Sample text

His temper was violent and passionate; he could bear no attack on the ideas which were dear to him, and became combative as soon as he thought them threatened. His was a wrestler's temperament; obstacles exasperated his energy and he went straight for them, pursuing his object with an invincible tenacity; he never gave up a problem, however difficult, and never hesitated to face any sacrifice or any privation if he thought them necessaiy. ([3] Life, p. 96) Metchnikoff returned to Odessa in 1872 (and remained on the university faculty until 1882).

Science will solve them some day. ([3] Life, p. 270) Metchnikoff's Autobiographical Retrospection of His Phagocytosis Hypothesis Dealing with the history of the phagocytosis hypothesis, one must be cautious concerning Metchnikoff's retrospective attempts to reconstruct its history. A complete account is found in the biography written by his wife, but the true coauthor of this work was Elie Metchnikoff himself: Often [recalls Olga Metchnikoff], when he was not too tired, he would sit comfortably in his armchair and recount to me with his usual spirit and animation some period or episode of his past.

Lancelet, a Chordata, has larvae that are similar to those of invertebrates, and Kowalevsky extended these observations to other lower metazoans, obtaining similar results. Metchnikoff first met Kowalevsky during the summer of 1865 in Naples. He recalled, "In Naples I was able to be convinced with my own eyes in the truth and importance of the discovery of the lancelet larvae" (20, p. 24). The discovery, according to Metchnikoff's testament, firmly established the fact that "vertebrates and invertebrates are connected by the indissoluble link of wandering by cilia lancelet larvae" (20, p.

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Metchnikoff and the Origins of Immunology: From Metaphor to Theory (Monographs on the History and Philosophy of Biology) by Alfred I. Tauber

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