By A.D. Roses, K.H. Weisgraber, Y. Christen
There is now huge genetic proof that the kind four allele of the apolipoprotein E gene is an incredible susceptibility issue linked to late-onset Alzheimer's affliction, the typical type of the sickness outlined as beginning after sixty years of age. The position of apolipoprotein E in general mind metabolism and within the pathogenesis of Alzheimer's ailment are new and intriguing avenues of study. This ebook, written through the main amazing scientists during this new filed, is the 1st presentation of effects about the implications of apolipoprotein E at the genetics, mobile biology, neuropathology, biochemistry, and healing administration of Alzheimer's disease.
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Additional resources for Apolipoprotein E and Alzheimer’s Disease
Finally, we examined the impact of a total loss of apoE on cognitive performance in young, 2-month-old apoE knockout mice using the Morris swim maze paradigm (Morris 1985). As cognitive performance (spatial memory and learning) in this test relies heavily (but not exclusively) on intact cholinergic functions, we hypothesize that the absence of apoE in these animals compromises cholinergic function and, indirectly, cognitive performance. Indeed, Fig. 3 displays the mean (±SEM) latency to find the platform for the apoE knockout and control mice across five days of testing.
Gracon, M. Farlow, and S. Gauthier Summary Recent evidence indicates that apolipoprotein E (apoE) plays a central role in the hippocampal response to injury. The coordinated expression of apoE and its receptor, the apoE/apoB (LDL) receptor, appears to regulate the transport of cholesterol and phospholipids during the early and intermediate phases of the reinnervation process. During dendritic remodelling and synaptogenesis, neurons progressively repress the synthesis of cholesterol in favor of cholesterol internalization through the apoE/LDL receptor pathway.
SCience 264 850--852 Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW (1987) Astrocytes synthesIZe apohpoprotem E and metabohze apohpoprotem E-contammg hpoprotems BlOchlm BlOphys Acta 917 148161 Roses AD, Saunders AM, Corder EH, Pencak-Vance MA, Han S-H, Emstem G, Hulette C, Schmechel DE, Holstl M, Huang D, Risch NJ, Hames JL, Goedert M, lakes R, Dong L-M, Welsgraber KH, Stnttmatter WJ (1995) Influence of the susceptlblhty genes apohpoprotem E-E4 and apohpoprotem E-E2 on the rate of disease expresslvlty of late-onset Alzheimer's disease Arznelm-Forsch/Drug Res 45 413-417 Sanan DA, Welsgraber KH, Russell Sl, Mahley RW, Huang D, Saunders A, Schmechel D, Wlslllewsk!
Apolipoprotein E and Alzheimer’s Disease by A.D. Roses, K.H. Weisgraber, Y. Christen