By Helmut Buschmann, J?rg Holenz, Antonio Párraga, Antoni Torrens, José Miguel Vela, José Luis D?az
Antidepressants and comparable psychiatric medicinal drugs are an important prescribed drugs around the globe, accounting for a industry quantity of 20 billion US$ in step with 12 months. This guide presents an entire and specific assessment of all presently to be had psychiatric medicines, masking greater than 250 varied compounds.
specific positive aspects include:
* an important info at the chemistry, pharmacology and healing use of a given drug
* a different structure with margin notes and compound constructions taking into consideration fast and straightforward entry to the specified information
Written by way of drug builders from the pharmaceutical undefined, novel medicinal drugs at present less than improvement and new tools of remedy are indexed facet by means of aspect with classical medications, permitting an immediate comparability of conventional and cutting edge healing approaches.Content:
Chapter 1.1 Introductory and simple features (pages 2–50): Luz Romero, Ana Montero, Begona Fernandez and Jose M. Vela
Chapter 1.2 Clinics (pages 51–110): Rosario Perez?Egea, Victor Perez, Dolors Puigdemont and Enric Alvarez
Chapter 1.3 Pharmacology (pages 111–140): Begona Fernandez, Luz Romero and Ana Montero
Chapter 1.4 Experimental study (pages 141–172): Ana Montero, Begona Fernandez and Luz Romero
Chapter 1.5 Chemistry (pages 173–296): Jorg Holenz, Jose Luis Diaz and Helmut Buschmann
Chapter 2.1 Introductory and simple elements (pages 298–334): Francesc Artigas
Chapter 2.2 Clinics (pages 335–388): Salvador Ros and Francisco Javier Arranz
Chapter 2.3 Pharmacology (pages 389–448): Analia Bortolozzi, Llorenc Diaz?Mataix and Francesc Artigas
Chapter 2.4 Experimental learn (pages 449–489): Pau Celada, Anna Castane, Albert Adell and Francesc Artigas
Chapter 2.5 Chemistry (pages 491–616): Antonio Parraga, Jorg Holenz and Helmut Buschmann
Chapter 3.1 Introductory and uncomplicated points (pages 618–880): Francisca Lopez?Rios, Serafin Gomez?Martin and Antonio Molina?Moreno
Chapter 3.2 Clinics (pages 881–894): Blanca Gutierrez and Jorge Cervilla
Chapter 3.3 Pharmacology (pages 895–922): Jose Manuel Baeyens
Chapter 3.4 Experimental learn (pages 923–949): Enrique Portillo and Jose M. Vela
Chapter 3.5 Chemistry (pages 951–1087): Monica Garca?Loapez, Susana Yenes, Helmut Buschmann and Antoni Torrens
Chapter 4.1 Introductory and easy facets (pages 1090–1103): Javier Burgueno, Rafael Franco and Francisco Ciruela
Chapter 4.2 Clinics (pages 1105–1154): Francisco Javier Arranz and Salvador Ros
Chapter 4.3 Pharmacology (pages 1155–1182): Francisco Ciruela, Rafael Franco and Javier Burgueno
Chapter 4.4 Chemistry (pages 1183–1196): Jorg Holenz, Jose Luis Diaz and Helmut Buschmann
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Proteins are essential to the structure, function, and regulation of the body. Examples are hormones, enzymes, and antibodies. Proteome Complete profile of all expressed (produced) proteins within a cell, a tissue, or an entire organism at a given time. Proteomics Analysis of the functions and interactions of proteins in healthy tissue compared to tissue affected by a disease. Proteomics includes the the separation, identification & characterisation of proteins present in a biological sample and comparison of disease and control samples to identify "disease specific proteins".
A partial agonist is an agonist which is unable to induce maximal activation of a receptor population, regardless of the amount of drug applied. Peptidomimetic Peptidomimetics are compounds containing non-peptidic structural elements that are capable of mimicking or antagonizing the biological action(s) of a natural parent peptide (IUPAC). PET A method that produces cross-sectional x-rays of metabolic processes by means of positron emission tomography. Pharmacokinetics Pharmacokinetics refers to the study of absorption, distribution, metabolism and excretion (ADME) of bioactive compounds in a higher organism (IUPAC).
Ion channel Receptor or carrier proteins which, when activated, allows the passage of ions across cell membranes. Isosteres Molecules or ions of similar size containing the same number of atoms and valence electrons. Lead / Lead compound As a result of the screening process used during drug discovery, active substances will be identified. Of these active substances, the compound that best fits the desired characteristics profile (pharmacological activity, lack of early toxicity, patentability, etc) will be declared a lead compound.
Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application by Helmut Buschmann, J?rg Holenz, Antonio Párraga, Antoni Torrens, José Miguel Vela, José Luis D?az