Antibody-Mediated Drug Delivery Systems: Concepts, - download pdf or read online

By Yashwant Pathak, Simon Benita

ISBN-10: 0470612819

ISBN-13: 9780470612811

ISBN-10: 1118229010

ISBN-13: 9781118229019

Content material:
Chapter 1 Antibody?Mediated Drug supply platforms: normal assessment and purposes (pages 1–12): Navdeep Kaur, Karthikeyan Subramani and Yashwant Pathak
Chapter 2 Immunoliposomes for Cardiovascular focusing on (pages 13–33): Tatyana Levchenko, William Hartner and Vladimir P. Torchilin
Chapter three Antibody?Mediated Drug supply platforms for Breast melanoma Therapeutics (pages 35–55): Leonor Munoz Alcivar and Yashwant Pathak
Chapter four improvement of Immunonconjugates for in Vivo supply: melanoma prognosis, Imaging, and treatment (pages 57–81): Arutselvan Natarajan
Chapter five Mathematical versions of Anti?TNF treatments and their Correlation with Tuberculosis (pages 83–104): Simeone Marino, Mohammad Fallahi?Sichani, Jennifer J. Linderman and Denise E. Kirschner
Chapter 6 special Nanoparticles in Radiotherapy (pages 105–128): Misty Muscarella and Yashwant Pathak
Chapter 7 Electrically?Enhanced supply of substances and Conjugates for melanoma remedy (pages 129–143): Arutselvan Natarajan, Luca Campana and Raji Sundararajan
Chapter eight Characterization of Monoclonal Antibody variations and Glycosylation (pages 145–167): Ting Zheng, Srinivasa Rao, Jeff Rohrer and Chris Pohl
Chapter nine Antibody?Mediated Drug supply procedure for Lymphatic focusing on remedy (pages 169–190): Fang Wu, Hong Ding and Zhirong Zhang
Chapter 10 tools for Nanoparticle Conjugation to Monoclonal Antibodies (pages 191–207): Junling Li and Chin okay. Ng
Chapter eleven Single?Use structures in Animal Cell–Based Bioproduction (pages 209–228): William G. Whitford
Chapter 12 Immunoliposomes for particular Drug supply (pages 229–266): Manuela Calin
Chapter thirteen Gene treatment concentrating on Kidney ailments: Routes and autos (pages 267–277): Yoshitaka Isaka, Yoshitsugu Takabatake and Hiromi Rakugi
Chapter 14 Detection of Antibodies to Poly(Ethylene Glycol) Polymers utilizing Double?Antigen?Bridging Immunogenicity ELISA (pages 279–290): Yijuan Liu, Helen Reidler, Jing Pan, David Milunic, Dujie Qin, Dave Chen, Yli Remo Vallejo and Ray Yin
Chapter 15 Antibodies in Nanomedicine and Microimaging equipment (pages 291–349): Rakesh Sharma
Chapter sixteen equipment for Polymeric Nanoparticle Conjugation to Monoclonal Antibodies (pages 351–363): Uyen Minh Le, Hieu Tran and Yashwant Pathak
Chapter 17 Plant?Derived Antibodies for tutorial, commercial, and healing functions (pages 365–381): Slavko Komarnytsky and Nikolai Borisjuk
Chapter 18 Monoclonal Antibodies as Biopharmaceuticals (pages 383–389): Girish J. Kotwal
Chapter 19 Pulmonary concentrating on of Nanoparticles and Monoclonal Antibodies (pages 391–405): Weiyuan Chang
Chapter 20 Antibody?Mediated Arthritis and New healing Avenues (pages 407–426): Kutty Selva Nandakumar
Chapter 21 Immunonanoparticles for Nuclear Imaging and Radiotherapy (pages 427–456): Oren Giladi and Simon Benita
Chapter 22 Monoclonal Antibodies within the therapy of bronchial asthma (pages 457–472): Glenn J. Whelan

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Additional info for Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications

Example text

These data show that the protective effect can lead to long-term preservation of cardiocyte viability, which should be especially important from a practical point of view for extended preservation of myocardial viability. 8 ACCUMULATION OF LIPOSOMES AND IMMUNOLIPOSOMES 21 +Immunoliposomes + IgGliposomes Hypoxic cardiocytes + Plain liposomes No treatment Normoxic cardiocytes 0 20 40 60 80 100 Cell viability (%) FIGURE 1 Cell viability of H9C2 cardiomyocytes with 24 h of hypoxia. Viability by trypan blue was assessed utilizing all cells in each culture flask in triplicates.

2010). Research and development of next generation of antibody-based therapeutics. Acta Pharmacol. Sin. 31(9); 198–207. 3. html. 4. aspx. 5. com/a-to-z-guides/immunoglobulins. 6. html. 7. org/wiki/IgE. REFERENCES 11 8. Steinitz, M. (2009). Three decades of human monoclonal antibodies: past, present and future developments. Hum. Antibodies. 18(1–2); 1–10. 9. Parker, D. C. (1993). T cell-dependent B cell activation. Annu. Rev. Immunol . 11, 331–360. 10. pdf. 11. org/wiki/B_cell. 12. org/wiki/Antibody.

These intrabodies showed promising results in in vitro studies, inhibiting NS3 protease activity and suppressing replication of HCV RNA when expressed intracellularly by DNA transfection in Huh 7 hepatoma cells. Also, antiNS3 scFvsintrabodies inhibited the replication of replicons A156T and R109K, responsible for conferring resistance to small-molecule antiviral candidates. Intrabodies specific for H-RAS and cyclin E have shown their usefulness in oncology by blocking transformation in cell culture.

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Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications by Yashwant Pathak, Simon Benita


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