By Harry G. Brittain
Even supposing the professional compendia outline a drug substance as to id, purity, power, and caliber, they in general don't supply different actual or chemical facts, nor do they record tools of synthesis or pathways of actual or organic degradation and metabolism. Such details is scattered through the medical literature and the documents of pharmaceutical laboratories. Edited via the affiliate Director of Analytical examine and improvement for the AmericanAssociation of Pharmaceutical Scientists, Analytical Profiles of Drug elements and Excipients brings this data jointly into one resource. The scope of the sequence has lately been increased to incorporate profiles of excipient fabrics.
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Extra info for Analytical Profiles of Drug Substances and Excipients, Volume 23 (Analytical Profiles of Drug Substances, Excipients, and Related Methodology)
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Recent studies have investigated the non-linearity of disposition kinetics after intravenous administrationusing a rat model [1921 and the nature of oral absorption [191,1931. The intravenous study indicated that non-linearity arises fiom renal elimination mechanisms, possibly saturation of active tubular secretion or reabsorption at high doses. Oral studies in the rat  showed that the plasma level curve is best fit by a combined zero and first order kinetic function, which also gives a good fit for human plasma level data.
Analytical Profiles of Drug Substances and Excipients, Volume 23 (Analytical Profiles of Drug Substances, Excipients, and Related Methodology) by Harry G. Brittain