Read e-book online Advances in Nuclear Architecture PDF

By Kendra L. Cann, Sui Huang, Graham Dellaire (auth.), Niall M. Adams, Paul S. Freemont (eds.)

ISBN-10: 9048198984

ISBN-13: 9789048198986

ISBN-10: 9048198992

ISBN-13: 9789048198993

This e-book presents a photo of the state-of-the artwork within the learn of mammalian phone nuclear structure, and contours a various diversity of chapters written by means of best researchers. A key point is an emphasis on detailed and repeatable quantitative research and simulation as well as the extra time-honored organic point of view. The fusion of such fabric frames the way forward for the self-discipline. Quantitative contributions pressure reproducible and strong 3D research, utilizing a number of instruments starting from aspect development research to form registration tools. organic insights contain the function of nuclear subdomains in melanoma, nuclear molecular cars, and a holistic view of gene transcription.

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1997 P130 UBF Ciarmatori et al. 2001 p53 SL1 Zhai and Comai 2000 The nucleolus only reassembles again in G1 once this repression is relaxed (reviewed in [Boisvert et al. 2007; Sirri et al. 2008]), and rRNA transcription is restarted by the G1 kinases CDK4-cyclin D1 and CDK2-cyclin E in preparation for another potential round of the cell cycle. These kinases phosphorylate UBF, another component of the preinitiation complex, and this promotes its recruitment of RNA polymerase I to the rDNA promoters, activating transcription (Voit et al.

As the site of rRNA transcription and ribosome biogenesis, the nucleolus is the canonical example of the relationship between structure and function in the nucleus (Dundr and Misteli 2001; Hernandez-Verdun 2006a). The very existence of the nucleolus depends on on-going rRNA transcription by RNA polymerase I and secondary rRNA processing events (Hernandez-Verdun 2006a; Sirri et al. 2008), and, as will be discussed below, the substructure of the nucleolus is organized around these processes. Mammalian cells typically contain one to a few nucleoli (Fig.

For example, nucleostemin, which is a marker for many stem cells and cancer cells, can suppress p53 after nucleolar disassembly by interfering with the interaction between MDM2 and RPL23 (Meng et al. 2008). In a contradictory scenario, ectopic nucleostemin has been shown to also activate p53 by binding to and inhibiting MDM2 function (Dai et al. 2008). Furthermore, depletion of nucleostemin causes increased binding of RPL5 and RPL11 to MDM2, again activating p53 (Dai et al. 2008). Therefore, the level of nucleostemin is closely monitored by the p53 pathway, with both depletion and overexpression of nucleostemin leading to p53 stabilization (Ma and Pederson 2008).

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Advances in Nuclear Architecture by Kendra L. Cann, Sui Huang, Graham Dellaire (auth.), Niall M. Adams, Paul S. Freemont (eds.)


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