Advances in Heterocyclic Chemistry, Vol. 96 by Alan R. Katritzky PDF

By Alan R. Katritzky

ISBN-10: 0123744334

ISBN-13: 9780123744333

The definitive serial within the box — on the grounds that 1960.* offers up to date fabric on a quick starting to be and hugely topical topic sector* comprises the newest study masking a large choice of heterocyclic subject matters* Written through major gurus and designed as a instruction manual for college kids and and educational researchers

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H2O2 (CCl3CO)2CO R = N-Me-pyrrol-3-yl S O O S H2O2 O N N H N Me O 175 S N O O Me 174 Me N H Me N O 176 Scheme 34 R X R X R X CH2I2, Zn-Cu O MeS SMe ether, reflux 61−63% SMe O IZn S Me SMe S I 177 178 Scheme 35 3. 1 Benzodiazepines with fused pyrrole ring The synthetic chemistry for these targets has been most extensively developed for benzopyrrolo[1,2]diazepines. It includes annulation of the pyrrole ring to a pre-formed benzodiazepine core, intramolecular cyclizations of non-cyclic precursors and 6 + 1 and 4 + 3 dicomponent cyclizations.

2 (1992SC1433)). 3 Miscellaneous ring systems Several other types of rings related to the reviewed cyclic systems have been reported (Figure 7). Structurally similar, most are out of the scope of the current review although they give insight into the possible diversity. Most of the systems described in this section have been synthesized using the methods mentioned above and the reader is referred to the individual references for this information. Syntheses of furano thiazepinones 354 by intramolecular Friedel–Crafts cyclizations have been reported (1995CPB2064).

2 Intramolecular cyclizations. 1 (2005T5489)). Benzoheteropines with Fused Pyrrole, Furan and Thiophene Rings 31 Imidazo[2,1-a]isoindolone 187 is the product of an intramolecular a-aza-amidoalkylation of N-acyliminium species 186. Nevertheless, when the b-substituent is an aromatic moiety, a competing a-amidoalkylation takes place and isoindolo[1,4]benzodiazepine 188 is obtained under thermodynamic control (Scheme 37 (2004T11029)). N-Aryl isoindolo[2,1-b][2,4]benzodiazepines 190 (Scheme 38, R ¼ Ar) can be obtained by an intramolecular acylation of amino acids 189 in acetic anhydride (1998T1497).

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Advances in Heterocyclic Chemistry, Vol. 96 by Alan R. Katritzky


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