Download e-book for iPad: Acute Leukemias: Prognostic Factors and Treatment Strategies by P. Dörmer, G. Ucci, Ch. Hershko, W. Wilmanns (auth.), Prof.

By P. Dörmer, G. Ucci, Ch. Hershko, W. Wilmanns (auth.), Prof. Dr. T. Büchner, Prof. Dr. G. Schellong, Priv.-Doz. Dr. W. Hiddemann, Prof. Dr. D. Urbanitz, Prof. Dr. J. Ritter (eds.)

ISBN-10: 3540165568

ISBN-13: 9783540165569

ISBN-10: 3642712134

ISBN-13: 9783642712135

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Extra info for Acute Leukemias: Prognostic Factors and Treatment Strategies

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More efficacious treatments and approaches associated with less morbidity have to be developed for this disease, which is still fatal for the majority of patients. References 1. Ymer S, Tucker WOJ, Sanderson CJ, Hapel AJ, Campbell HD, Young IG (1985) Constitutive synthesis of interleukin-3 by leukaemia cell line WEHI 3B is due to retroviral insertion near the gene. Nature 317:255 2. Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER (1985) The c-fms prto-oncogene product is related to the receptor for the mono nuclear phagocyte growth factor, CSF-1.

Cytochemical examination of bone marrow and blood smears included the following reactions according to standard procedures: (a) myeloperoxidase, (b) periodic acid Schiff reaction (PAS), (c) acid naphthyl acetate esterase (ANAE), (d) acid phosphatase (AcP), (e) dipeptidylaminopeptidase IV (DAP IV) [3]. Terminal deoxynucleotidyl transferase (TDT) was qualitatively determined by immunofluorescence [4] using commercially available antisera (Bethesda Research Labs, Eggestein, Federal Republic of Germany; P-L Biochemical, St.

Comparing F AB categories with cytochemical phenotypes, there is a significant correlation between AcP and Ll and between DAP IV and Ll, which in both cases can be related to immunophenotypes with more statistical power and clinical relevance. In addition, we compared the cytochemical 25 patterns described earlier with the immunophenotypes determined in our study (see Thiel et aI, this volume). There is a highly significant correlation between focal AcP and the T and, to a lesser degree, the pre-T phenotypes, compared with only a small proportion of C/pB and O-ALL disclosing this pattern of AcP reaction.

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Acute Leukemias: Prognostic Factors and Treatment Strategies by P. Dörmer, G. Ucci, Ch. Hershko, W. Wilmanns (auth.), Prof. Dr. T. Büchner, Prof. Dr. G. Schellong, Priv.-Doz. Dr. W. Hiddemann, Prof. Dr. D. Urbanitz, Prof. Dr. J. Ritter (eds.)


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